Genome Cure for Ill Twins Paves Breakthrough to Doctor's Office
The company's machines revealed that the twins had been misdiagnosed and incompletely treated for more than a decade. New medication put an end to an illness that had caused vomiting, muscle weakness and seizures. Their daughter, who had spells of breathing difficulties that turned her skin blue, was healthy again.
“Genome sequencing literally saved her life,” Retta Beery said. Nine years after scientists sequenced the first complete human genome -- the instruction manual for making all the body's cells -- the industry is poised for a series of takeovers and technological breakthroughs that will bring the technology into doctor's offices and patient hospital rooms. Equipment made by Life Technologies and Illumina Inc. is spewing out human genome sequences faster than ever and prices will soon drop to $1,000, below that of many widely used diagnostic procedures, such as colonoscopies.
Roche Holding AG's hostile $5.7 billion bid for Illumina may spark additional deals as pharmaceutical and diagnostic companies race to bring DNA scanning into routine medical use, analysts said.
Eoin Treacy's view The
Nasdaq-100 hit a new 11-year high last
week following an impressive rally. Some consolidation of at least part of those
gains is increasingly likely. However, its relative strength is perhaps more
important because it is one of only three indices to have hit new highs since
the Q3 correction.
Apple
remains a totem in the Index but biotechnology and pharmaceuticals have also
been among the better performers and these sectors display greater commonality.
M&A activity has also picked up with Roche acquiring Illumina,
Amgen acquiring Micromet and Fujifilm
acquiring SonoSite.
Biotechnology
is an exciting sector. It promises to change not only how we live our lives
but to extend our life expectancy though personalised medicine. The sector went
through a difficult decade following the TMT bust where venture capital evaporated
and only the strongest survived. However these same companies have been highly
productive and a number are on the cusp of releasing ground breaking products.
Investors are responding in kind and a considerable number of shares broke out
of long-term bases last year. (Also see Comment of the Day on October
27th & 28th
for a review of pharmaceutical and biotech shares).
Here
is a spread sheet of biotechnology
shares ranked by market cap.
Biogen
completed an 11-year base, when it hit a new high in April 2011, and continues
to extend the uptrend which remains reasonably consistent.
Celgene
consolidated in the region of the upper side of an almost three-year range from
October and has since rallied to test the 2008 peak. Amgen
broke out of a three-year range in December. Gilead
Sciences broke out of two-year range two weeks ago.
Alexion
Pharmaceuticals remains in a consistent, albeit steep uptrend. A sustained
move below $60 would be required to question medium-term potential for additional
upside.
Life
Technologies dropped abruptly in August but has recouped the entire decline.
It will need to hold the majority of its January advance, on the next pullback,
if the medium-term upside is to continue to be given the benefit of the doubt.
In
the mid-cap portion of the sector: ResMed
rallied impressively last week, on strong earnings, to challenge the 18-month
ranging downtrend, Cubist Pharmaceutical
completed a five-year base in April and continues to find support in the region
of the MA on reactions. Seattle Genetics
found support in the region of the upper side of the previous range from August
and is currently rallying towards the October peak. Myriad
Genetics has held a progression of higher reaction lows since August 2010
and is currently rallying towards the upper side of its range. Halozyme
Therapeutics completed a three-year range in October and is currently testing
the 2007 peak. Medicines Company bottomed
in 2010 following a lengthy decline and remains on a recovery trajectory. Immunogen
pulled back to test the upper side of its seven-year base in July and also remains
on a recovery trajectory.
In
the less than $1 billion market cap portion of the sector: ArQule
has held a progression of higher major reaction lows since 2008 and surged two
weeks ago to test the upper side of the long-term base near $8. Staar
Surgical broke out of a yearlong range in August and continues to trend
consistently, albeit steeply, higher. Curis
appears to be in the process of completing an almost decade long base. Nymox
Pharmaceuticals continues to consolidate above the $7 area following its
breakout last year.
The
commonality evident in the biotech sector reflects heightened investor interest
both in the prospect of increased M&A activity and the potential for significant
innovation to improve earnings potential.